The fundamental intractable problem with prevailing rationalistic-mechanistic milieu: only that which can be quantified & measured is real to modern mind 🤷
‘Tis long overdue for us to re-learn the skills to live with uncertainty, without flying our increasingly feeble selves over cuckoo's nests 😊
I suggest a particularly good paper on using surrogate endpoints in clinical research. A bit "old" but has 1872 citations.
https://www.acpjournals.org/doi/10.7326/0003-4819-125-7-199610010-00011
It clarifies why it is difficult and, in fact, almost impossible to validate a surrogate to a clinical endpoint.
The fundamental intractable problem with prevailing rationalistic-mechanistic milieu: only that which can be quantified & measured is real to modern mind 🤷
‘Tis long overdue for us to re-learn the skills to live with uncertainty, without flying our increasingly feeble selves over cuckoo's nests 😊